Syrian Rue Extract 10x — Peganum harmala

Syrian Rue Extract 10x is a concentrated ethnobotanical preparation derived from the seeds of Peganum harmala, a plant with a long history in the traditional cultures of Iran, Afghanistan, Turkey and other parts of the Middle East and Central Asia.

The seeds naturally contain harmala alkaloids, including harmine and harmaline. These compounds are recognised for their reversible monoamine oxidase-inhibiting (MAOI) activity, making Syrian rue an important subject in ethnobotanical and phytochemical research.

Because MAO-inhibiting compounds can interact seriously with medicines and other substances, the safety information should be read carefully before handling or using this product. Each pack contains 1 g of 10x Syrian rue extract in hermetically sealed packaging.

About Syrian Rue (Peganum harmala)

Peganum harmala is a hardy perennial plant belonging to the Nitrariaceae family. It is naturally found across dry and semi-arid regions extending from the Mediterranean and North Africa through the Middle East and Central Asia towards north-western India.

The plant generally grows to around 30–80 cm in height and produces white flowers followed by rounded seed capsules containing numerous dark seeds. These seeds are particularly valued for their naturally occurring beta-carboline alkaloids.

Syrian rue is also known by names including harmal, esfand and rue, depending on the region and cultural context.

Traditional and Cultural Heritage

Peganum harmala has a particularly rich ethnobotanical history. In Persian, Turkish, Arabic and neighbouring cultures, its seeds have traditionally been burned as incense or used in fumigation rituals.

Historical practices have associated the smoke of burning seeds with protection, purification and the warding off of the evil eye. Syrian rue also appears in various forms of traditional herbal and spiritual practice throughout the Middle East and Central Asia.

Modern ethnobotanical research has further focused on Peganum harmala because of its naturally occurring harmala alkaloids and their role in traditional plant preparations.

Naturally Occurring Compounds

Syrian rue seeds contain several biologically active constituents, particularly beta-carboline alkaloids such as:

• Harmaline
• Harmine
• Harmalol
• Tetrahydroharmine
• Vasicine (peganine)

Harmine and harmaline are especially notable because of their reversible monoamine oxidase-inhibiting properties.

What Does “10x” Mean?

The term 10x refers to the concentration ratio used to describe the extract. In product terms, it indicates that approximately 10 parts of the original dried seed material have been concentrated into one part of extract.

As a result, the extract is considerably more concentrated than unprocessed Syrian rue seeds. The alkaloid content can vary depending on the source material and extraction process, so the stated concentration ratio should not automatically be interpreted as a fixed alkaloid percentage.

Product Details

• Botanical name: Peganum harmala
• Product: Syrian Rue Extract 10x
• Quantity: 1 g
• Source: Syrian rue seeds
• Form: Concentrated botanical extract
• Packaging: Hermetically sealed

Important Safety Information

⚠ MAO-INHIBITOR WARNING

Syrian rue contains harmala alkaloids with reversible MAO-inhibiting activity. MAO inhibitors can produce significant and potentially dangerous interactions with medicines, recreational substances and certain foods.

For safety:

• Do not combine with antidepressants or other serotonergic medicines.
• Do not combine with pharmaceutical or botanical MAO inhibitors.
• Do not combine with stimulants or other psychoactive substances.
• Particular caution is required with opioids, tramadol and dextromethorphan.
• Do not use during pregnancy or breastfeeding.
• People with cardiovascular conditions, hypertension or liver problems should avoid use unless specifically advised otherwise by a qualified healthcare professional.
• If you take prescription or over-the-counter medication, seek professional medical advice before considering this product.
• Keep out of reach of children.

Potentially serious drug interactions can occur even when substances are taken separately within a relatively short period. Anyone experiencing severe symptoms such as confusion, extreme agitation, significant changes in blood pressure, chest pain, seizures or loss of consciousness should seek urgent medical attention.

Storage

Keep the extract tightly sealed and store it in a cool, dry and dark location, away from direct sunlight, moisture and excessive heat.

This product is an ethnobotanical preparation and is not a medicine or a substitute for a varied, balanced diet and healthy lifestyle. Regulations concerning Peganum harmala and concentrated harmala alkaloid preparations vary between countries, so always check the legislation applicable in your country before purchasing or possessing the product.